| ABSTRACT Objective:To probe into the characteristics of adverse drug reactions (ADR) caused by antitumor drugs and to provide some rational clinical guidance.Method:661 reports of adverse reactions caused by antitumor drugs were collected in a 3A-Grade Hospital from January 2004 to December 2008 and statistically analyzed in respect of patients’ sex and age, involved drugs, routes of administration, clinical manifestations, rating of correlated factors, etc. Result:Of the 661 cases, 65.5%were male cases (430) and 34.95%, female cases; 191 cases (38.43%) were the elderly at the age of more than 60 and 1 145 case times were involved in 64 kinds of antitumor drugs. The incidence rate of ADRs induced by cisplatin (210 case-times), fluorouracil (135 case-times) and oxaliplatin (124 case-times) took the front 3 places in the sequence. Drugs for intravenous administration resulted in the highest rate with 1027 case times (89.69%).1566 adverse reactions occurred, of which there were 773 cases of digestive system lesion (49.36%) that ranked the first. The incidence rate of new and severe ADR was 36.6%, accounting for 242 cases.Conclusion:The collection and arrangement of adverse drug reactions and analysis and evaluation of their basic information were helpful to ensure and promote safe and rational clinical administration. |
