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| 多奈哌齐联合认知康复训练治疗认知障碍 |
| Effects of Rehabilitation Training Combined with Donepezil on the Cognitive Impairment Patients |
| 投稿时间：2012-01-20 修订日期：2012-03-31 |
| DOI： |
| 中文关键词: 轻度认知障碍 多奈哌齐 康复训练 |
| 英文关键词:Mild cognitive impairment Donepezil Rehabilitation |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：探讨多奈哌齐联合认知康复训练治疗轻度认知障碍的临床疗效。 方法：90例轻度认知障碍患者随机分为2组，联合治疗组口服多奈哌齐联合认知康复训练治疗，对照组仅口服多奈哌齐，跟踪观察6个月，治疗前后均进行简易精神状态检查表（MMSE）评分与临床记忆量表检查，并对结果进行统计分析。结果：治疗后联合治疗组的MMSE评分和临床记忆量表测定中指向记忆、联想学习、人像特点联系回忆及总分等方面评分明显优于对照组，差异有统计学意义(P<0.05)。结论：治疗后两组患者认知功能均有改善，多奈哌齐联合认知康复训练治疗明显优于单用口服多奈哌齐治疗。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical efficacy rehabilitation training combined with the donepezil on the cognitive impairment patients with mild cognitive disorders. Methods:90 cases of mild cognitive impairment patients were randomly divided into two groups：combined therapy group and only donepezil group, therapy tracking observed for 6 months. The efficacy were assessed with mini mental state to check the table (MMSE) and clinical memory scale before and after treatment, and the results were statistically analyzed. Results:MMSE score , determination of point to memory , associative learning , portrait characteristic associate memories and total score of clinical memory scale of the combined treatment group were significantly better than the control group after treatment(P<0.05) .Conclusion:The cognitive function in patients shows some improvements after treatment. The efficacy of rehabilitation practice combined with the donepezil is significantly better than only donepezil treatment . |
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