| ABSTRACT Objective: To observe the effect of hemp seed oil on the blood lipid and its hepatoprotective efficacy in hyperlipidemic rats. Methods: High fat diet was used to make the hyperlipidemia model in SD rats, and the rats were randomly divided into 6 groups: the normal control group，high fat model group, high dose group(1.5 g·kg-1), medium dose group (1.0 g·kg-1), low dose group (0.5 g·kg-1) and Xuezhikang group(0.5 g·kg-1). After 35 day treatment, serum TC, TG,HDL-C, LDL-C, SOD, MDA, ALT, AST and liver SOD were detected. Results: Compared with the model group, hemp seed oil at different dosages could significantly decrease the contents of serum TC, TG, ALT and the atherogenic index (AI)( P<0.05 or P<0.01), and significantly increase the SOD activity in serum and liver (P<0.01). The contents of serum MDA and AST in the medium and high dose groups were significantly decreased (P<0.01), and the content of LDL-C in serum and the content of MDA in liver in the high dose group were significantly reduced (P<0.01). Conclusion:Hemp seed oil shows promising blood lipid reducing ability and liver protective effect in hyperlipidemic rats, and the mechanism may be related with liver lipid metabolism improvement and antioxidant function enhancement. |
