| ABSTRACT Objective::To investigate the sedative effects of dexmedetomidine on patients with craniocerebral injury, and to analyze its adverse reactions. Methods:: 90 cases of craniocerebral injury patients selected from the ICU ward were randomly divided into observation group and control group with 45 cases either. The observation group received their dexmedetomidine injection sedative treatment, and the control group were given midazolam sedation therapy. The sedative effects, mechanical ventilation time, adverse reactions and time needed from stopping to waking up were compared between the two groups.Results::The treatment was successfully completed in the two groups. The treatment of the observation group reached the average time and calm times required by the target sedation. The target sedation times achieved by the treatments were better than those of the control group. VAS score was significantly lower in the observation group than that in the control group, and the differences were statistically significant (P<0.05). The time of mechanical ventilation and time required from stopping to waking up were shorter in the observation group than those in the control group, and the difference was statistically significant (P<0.05); no significant difference occurred in the number of adverse reactions of both groups(P>0.05).Conclusion::The sedative effect of dexmedetomidine on ICU patients with craniocerebral injury was significantly obvious, time of waking up was short, no respiratory depression occurred, and circulation stability could be better maintained, and therefore, it was worth clinical promotion. |
