| ABSTRACT Objective:Discuss the clinical effect and safety of dinoprostone being used in late pregnancy patients. Methods:Three hundred and sixty cases of late pregnant women were randomly divided into observation group and control group with 180 cases in each.The control group waere given oxytocin, the observation group were given dinoprostone suppositories to induced labor. The differences of cervical Bishop score before and after treatment,cervical ripening rate, clinical effect, the successful rate of induced labor, labortime, mode of delivery, neonatal outcome and adverse drug reaction of the two groups were compared.Results: After treatment,the Bishop score of two groups was significantly higher than non treatment(P<0.05), and the score of observation group was higher than control group(P<0.05). The observation group in cervical ripening rate, induction of labor the success rate, labor time, the rate of vaginal delivery were significantly better than the control group and the differences were statistically significant (P<0.05).To evaluate the clinical effect of the two groups after the treatment, the observation group in significant efficiency (45%), and the total efficiency (95%) was significantly higher than that of the control group (35.56%,88.89%),the differences were statistically significant in the assessment (P<0.05). There were no statistically significant between the difference of the two groups in the intrauterine distress,metrypercinesia, neonatal Apgar score(P>0.05). Conclusion:Dinoprostone suppositories in late pregnancy induced labor patients, not only can improve ripening, the success rate of induced labor and other indicators, save labor time, but also can reduce the sympton such as intrauterine distress, metrypercinesia, postpartum bleeding and other symptoms.The clinical efficacy was better than oxytocin. |
