| ABSTRACT Objective:To investigate the clinlical efficacy and safety of polyvinyl alcohol eye drops in prevention and treatment of dry eye.Methods:As retrospective analysis being applied,the medical record of 520 patients with dry eye were collected.Then,they were divided into observation group and control group with 260 patients respectively.The observation group were given the treatment of polyvinyl alcohol eye drops,The control group,on the other hand,were supplied 0.1% sodium hyaluronate eye drops.The patients in both two groups were compared the differences of dry eye level,congestion score , tear secretion test (SIT), tear break up time(BUT), corneal fluorescein staining test(FL), before the treatment and after the treatment of 1or 2 weeks . In this way to evaluate the clinical efficacy between two groups.Results:Before treatment, the difference between two groups of patients with clinical symptoms integral,dry eye level, congestion score, FL, BUT, SIT was not statistically significant (P>0.05); After treatment,the treatment group and the control group in clinical symptom, dry eye level, congestion score, FL, BUT, SIT index for first weeks and treated with statistical significance after 2 weeks were improved differing in degrees compared with non treatment(P<0.05);Besides, the result of observation group was better than control groupt(P<0.05) ; The cure rate and total efficiency rate in treatment group was significantly higher than that in the control group(P<0.05), the efficacy of two groups distribution in treatment group was superior to that in the control group(P<0.05); The rate of adverse drug reaction between two groups was not statistically significant(P>0.05) .Conclusion:Polyvinyl alcohol eye drops in treatment of dry eye disease has significant clinical efficacy and it is worthy of clinical application. |
