| ABSTRACT Objective:To observe the clinical curative effect of oxaliplatin combined S-1 on the treatment of patients with advanced colon cancer.Methods:Sixty cases of advanced colon cancer patients were divided into control group and observation group by the hospitalization time sequence with 30 patients each. Control group: the use of oxaliplatin, 130 mg·m-2, ivd qd; the observation group: the use of oxaliplatin, 130 mg·m-2, ivd qd; S 1 capsule 80 mg·m-2·d-1.After 4 cycles of treatment, the clinical efficacy ,adverse drug reaction , the effect on cell factor and the quality of life were observed and compared in patients of the two groups.Results: The efficient of observation group was 90.00% which was significantly higher than control group (P<0.05) After treatment,there were a significant rise in the two groups of serum IL-2 and TNF-α and IFN-γ levels compared with before treatment,(P<0.05),besides, observation group rose more significantly (P<0.05). Two groups of patients quality of life scores were significantly improved, but the data in observation group improved more apparent than in the control group (P<0.05).The rate of adverse drug reaction of the observation group was much lower than the control group (P<0.05).Conclusion:Oxaliplatin combined S 1 canpsule on the treatment of advanced colon cancer patients, it can improve the clinical curative effect,and can also effectively improve the patients' immune function, enhance the quality of life of patients with resistance ,and decrease adverse effect. |
