| ABSTRACT Objective:To compare the quality of recovery in elder laparoscopic cholecystectomy patients under general anesthesia maintained by sufentanil and fentanyl.Methods:Sixty elder patients with selective laparoscopic cholecystectomy were randomly divided into 2 groups: sufentanil group(Group S) and fentanyl group(Group F).Anesthesia was inducted with sufentanil 0.4 g·kg-1(group S) or fentanyl 4 g·kg-1 (group F) , midazolam 0.1 mg·kg-1, vecuronium 0.12 mg·kg-1, propofol 2 mg·kg-1. Sufentanil 10 g (group S) or fentanyl 0.1mg(group F) was injected 20min before the end of operation. Hemodynamics parameters during the period of tracheal extubation, the time of tracheal extubation, the incidence of postoperative pain ，the untoward effects as well as the number of patients asking for analgesic therapy were investigated. Results: During the period of tracheal extubation,the systolic blood pressure,diastolic blood pressure and heart rate were higher than before anesthesia（Ｐ＜0.01）.The systolic blood pressure,diastolic blood pressure in group F were higher than those in group S（Ｐ＜0.01）. Compared with group F, the time of tracheal extubation in group S was shorter, VAS score was lower（Ｐ＜0.01）， both the rate of untoward effects and the number of patients asking for analgesic therapy was much fewer（P<0.05）.The incidence of adverse drug reactions in S group was much lower than inthe F group（Ｐ＜0.01）.Conclusion:Using sufentanil in elder laparoscopic cholecystectomy patients under general anesthesia provides a shorter time of tracheal extubation with a lower rate of postoperative pain, a more stable hemodynamic environment, and a lower rate of untoward effects postoperation. |
