| ABSTRACT Objective: To analyze and evaluate the usage and tendency of quinolones before and after the special rectification of antibacterial in one grade III level A hospital in Nanjing to provide evidence for the special rectification of antibacterial and management. Methods: The usage records of quinolones in 2010 (before the special rectification) and in 2011 2013 (after the special rectification) were collected, and the sales revenue, DDDs, defined daily cost (DDC), drug resistance and adverse drug reactions (ADR) were analyzed retrospectively. Results: Both the amount and ratio of the sales revenue of quinolones were declined dramatically after the rectification (2011 2013). Among all kinds of quinolones, the sales revenue and DDDs of lomefloxacin aspartate injections was the highest before the rectification while moxifloxacin injections and levofloxacine hydrochloride injections ranked the first and the second respectively in sales revenue after the rectification(2012 2013). As for the DDDs, levofloxacin hydrochloride tablets and levofloxacine hydrochloride injections were the highest after the rectification. Besides, moxifloxacin injections had the highest DDC after the rectification. Moreover, the drug resistance of the main drug resistant bacteria (namely staphylococcus, enterobacteriaceae and non fermentation bacteria) to levofloxacin, norfloxacin and ciprofloxacin was declined after the rectification. The adverse drug reactions of levofloxacin, lomefloxacin, enoxacin and moxifloxacin were declined year by year after the rectification, and the ADR ratio of quinolones in all anti bacterial agents was also declined.Conclusion:After the special rectification of antibacterials, the hospital exhibits obvious improvement in all the application indices of antibacterials, reflecting a good result of the special rectification. However, the hospital still needs to strengthen the inspection over the clinical application of the fourth generation of quinolones. |
