| ABSTRACT Objective: To investigate the effect and safety of sertraline tablets with oral administration in the diabetes patients complicated with depression． Methods: Totally 74 diabetes patients complicated with depression were randomly divided into 2 groups with 37 ones in each. All the patients were orally given dimethyldiguanide 500 mg，tid, and the observation group was given sertraline tablets additionally, 50 100 mg, qd. The treatment course was 8 weeks. The changes of sugar metabolism and the scores of self rating depression scale (SDS) and quality of life scale (DMQLS) in the two groups were compared. Results: After the 8 week treatment, the blood sugar, SDS scores and DMQLS scores in the two groups were significantly improved when compared with those before the treatment (P<0.05). The levels of FBG, 2hPG and HbAlc and SDS scores in the observation group were significantly lower than those in the control group (P<0.05), while the scores of DMQLS disease, psychology, society and satisfaction dimension were significantly higher in the observation group (P<0.05). The incidence of adverse reactions showed no statistically significant difference between the two groups (P>0.05). Conclusion:Sertraline tablets can improve the depression of diabetes patients and enhance the blood sugar control and quality of life. |
