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| 干扰素α-2b抗青光眼滤过术后瘢痕形成的临床观察 |
| Clinical Effect of Interferon α-2b on Scar Formation after Glaucoma Filtering Surgery |
| 投稿时间：2014-09-26 修订日期：2015-01-18 |
| DOI： |
| 中文关键词: 干扰素α-2b；青光眼滤过术；术后瘢痕 丝裂霉素C |
| 英文关键词:Interferon α-2b Glaucoma filtering surgery Postoperative scar Mitomycin C |
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| 中文摘要: |
| 摘 要 目的： 探讨干扰素α 2b在抗青光眼滤过术后瘢痕形成的应用。方法: 原发性青光眼患者62例（68眼），随机分为观察组31例（36眼）、对照组31例（32眼），观察组患者术中给予干扰素α 2b浸润的棉片湿敷，而对照组给予丝裂霉素C浸润的棉片进行湿敷，术后随访4个月，比较两组患者术后滤过泡类型、并发症、眼压变化情况。结果:观察组患者以II型滤过泡为主（58.33%）、对照组患者以I型滤过泡为主（53.13%），两组滤过泡类型比较差异具有统计学意义（P<0.05）；两组患者术后各时间点眼压与术前比较，均有显著降低（P<0.05）；两组间各时间点眼压差异均无统计学意义（P>0.05）。观察组术后视力不变或提高的比例显著高于对照组（P<0.05）；且观察组患者发生术后并发症发生率显著低于对照组（P<0.05）。结论: 干扰素α 2b是一种较为理想的抗青光眼滤过术后瘢痕形成药物。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the preventive efficacy of interferon α-2b on scar formation after glaucoma filtering operation. Methods: Totally 62 patients with primary glaucoma (68 eyes) were randomly divided into the observation group (31 cases with 36 eyes) and the control group (31 cases with 32 eyes). The patients in the observation group were given wet compress with a piece of cotton infiltrated by interferon α-2b, while the control group was given wet compress with a piece of cotton infiltrated by mitomycin C. After 4 month postoperative follow up, the type of filtering bleb, complications and the changes of intraocular pressure were compared between the two groups. Results: The observation group was mainly with type II bleb (58.33%), while the control group was mainly with type I bleb (53.13%), and there was significant difference in the filtering bleb type between the two groups (P<0.05). After the operation, the intraocular pressure at each time point in the two groups was decreased significantly when compared with that before the operation (P<0.05), while the difference between the two groups was not statistically significant（P>0.05）. The percentage of visual invariableness or improvement in the observation group was significantly higher than that in the control group (P<0.05), and the occurrence of complications after the operation in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Interferon α 2b is an ideal drug for anti scarring formation after glaucoma filtration surgery. |
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