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| 铝碳酸镁联合奥美拉唑对胃溃疡合并胃出血的疗效分析 |
| Curative Effect Analysis of Hydrotalcite Combined with Omeprazole in the Treatment of Gastric Ulcer with Gastrorrhagia |
| 投稿时间：2014-08-05 修订日期：2015-01-19 |
| DOI： |
| 中文关键词: 铝碳酸镁 奥美拉唑 胃溃疡 胃出血 疗效 |
| 英文关键词:Hydrotalcite Omeprazole Gastric ulcer Gastric bleeding Curative effect |
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| 中文摘要: |
| 摘 要 目的： 探讨铝碳酸镁联合奥美拉唑治疗胃溃疡合并胃出血的疗效。方法: 76例胃溃疡合并胃出血患者随机分成两组，对照组（32例）单独使用奥美拉唑治疗，观察组（44例）联合奥美拉唑、铝碳酸镁治疗，比较两组的治疗效果。结果:观察组治疗总有效率100.0%，对照组总有效率87.5%，两组差异有统计学意义（P<0.05）；观察组治疗后症状综合评分（4.2±1.2）分，对照组（6.2±1.4）分，差异有统计学意义（P<0.01）；观察组腹痛、腹胀、嗳气缓解时间略短于对照组（P>0.05），呕血和便血缓解时间明显短于对照组（P<0.05）；3个月后观察组再出血发生率略少于对照组（P>0.05）。两组药品不良反应发生率差异无统计学意义（P>0.05）。结论: 铝碳酸镁联合奥美拉唑治疗胃溃疡合并胃出血的疗效明显，安全性良好。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative effect of hydrotalcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding. Methods: Seventy six patients with gastric ulcer and bleeding in the stomach were selected and randomly divided into two groups. Thirty two patients in the control group were treated with omeprazole alone while 44 patients in the observation group were treated with hydrotalcite combined with omeprazole. The therapeutic effects were compared between the two groups. Results: The total effective rate in the observation group was 100% while that was 87.5% in the control group，and the difference between the two groups was statistically significant (P<0.05). The comprehensive score of symptoms of the patients in the observation group was (4.2 ±1.2) while that was (6.2 ±1.4) in the control group，and the difference was significant (P<0.01). The abdominal pain，abdominal distention and belching remission time in the observation group were slightly shorter than those in the control group (P<0.05) and the time of hematemesis and hemafecia remission was significantly shorter than that in the control group (P<0.05). After the 3 month treatment, the re bleeding rate in the observation group was 6.82%, which was slightly better than that in the control group, and the difference had no statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 9.09% while that was 6.25% in the control group, and there was no significant difference between the two groups (P>0.05). Conclusion:Hydrotalcite combined with omeprazole in the treatment of gastric ulcer with gastric bleeding is effective and safe. |
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