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| 比索洛尔对CHF合并COPD患者心肺功能影响的回顾性研究 |
| A Retrospective Study of the Effects of Bisoprolol on Cardiopulmonary Function in Patients with CHF Complicated with COPD |
| 投稿时间：2014-09-25 修订日期：2014-12-16 |
| DOI： |
| 中文关键词: 比索洛尔 慢性心力衰竭 慢性阻塞性肺疾病 心肺功能 |
| 英文关键词:Bisoprolol Chronic heart failure Chronic obstructive pulmonary disease Cardio pulmonary function |
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| 中文摘要: |
| 摘 要 目的： 探讨比索洛尔对慢性心力衰竭（CHF）合并慢性阻塞性肺疾病（COPD）患者心肺功能的影响。方法: 采用回顾性研究方法，60例CHF合并COPD患者按治疗方法不同分为对照组和观察组各30例。对照组采用强心、扩冠、抗凝、营养心肌等常规方法治疗，观察组在对照组基础上加用比索洛尔片治疗，初始剂量为1.25 mg，根据患者耐受情况每1～2周增加1.25 mg，直至10 mg维持治疗。比较两组患者治疗3个月前后的心肺功能及临床疗效、药品不良反应。结果:观察组完全缓解率和有效率均明显高于对照组（P<0.05）。治疗后两组患者各项心功能指标均明显改善（P<0.05），且观察组改善情况优于对照组（P<0.05）。两组患者治疗前后肺功能均无明显变化（P>0.05）。两组药品不良反应发生率比较，差异无统计学意义（P>0.05）。结论: 比索洛尔联合常规治疗对CHF合并COPD患者的心功能具有良好的改善效果，且对患者肺功能不良影响甚微，安全有效，值得推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of bisoprolol on the cardiopulmonary function in the patients with CHF complicated with COPD. Methods: A retrospective study was used. Totally 60 cases of patients were divided into the observation group (30 cases) and the control group (30 cases) according to the different treatment method. The patients in the control group were treated with conventional methods including cardiotonic drugs, vasodilators, anticoagulation, myocardial nutrition and so on, while the patients in the observation group were treated with bisoprolol additionally at the initial dose of 1.25mg, and the dose was increased to 10mg at the rate of 1.25 mg/1-2 weeks. The cardiopulmonary function, clinical efficacy and adverse reactions of the two groups were compared after 3 month treatment. Results: The complete response rate and effective rate of the observation group were both higher than those of the control group（P<0.05）. All indices of cardiac function were improved in the two groups after the treatment（P<0.05）, and the improvement of the observation group was better than that of the control group（P<0.05）. There was no obvious change in the pulmonary function before and after the treatment（P>0.05）. The incidence of adverse reactions in the two groups showed no significant difference（P>0.05）. Conclusion:Bisoprolol combined with conventional treatment can improve cardiac function of the patients with CHF and COPD. The adverse effect on lung function is mild. Bisoprolol is safe and effective, which is worthy of promoted application. |
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