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| 左乙拉西坦添加疗法治疗青年难治性部分性癫痫疗效及对患者认知功能的影响 |
| Levetiracetam Additive Treatment for Refractory Partial Epilepsy in Young People and its Effects on Cognitive Function |
| 投稿时间：2014-09-04 修订日期：2015-01-28 |
| DOI： |
| 中文关键词: 左乙拉西坦 添加疗法 难治性部分性癫痫 认知功能 |
| 英文关键词:Levetiracetam Additive therapy Refractory partial epilepsy Cognitive function |
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| 中文摘要: |
| 摘 要 目的： 探讨左乙拉西坦（LEV）添加疗法治疗青年难治性部分性癫痫的疗效，及对患者认知功能的影响。方法: 62例难治性部分性癫痫青年患者随机分为A组（n=32）和B组（n=30）。B组给予苯巴比妥片+卡马西平片治疗，A组在B组基础上加用左乙拉西坦片。均持续给药6个月后，比较两组临床疗效、患者认知功能及生活质量差异，以及药品不良反应发生情况。结果:治疗后，A组治疗后12周与24周的总有效率均明显高于B组（P<0.05）；A组患者MoCA评估及SF 36评估评分也均优于B组（P<0.05）。两组药品不良反应发生率比较，差异无统计学意义（P>0.05）。结论: 对患难治性部分性癫痫的青年患者给予常规药物联合LEV疗法，疗效确切，对其认知功能的提升具有积极意义，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of levetiracetam (LEV) in the treatment of refractory partial epilepsy in young people and its effect on cognitive function.Methods: Totally 62 young patients with refractory partial epilepsy were randomly divided into the levetiracetam group (group A,n=32) and routine treatment group (group B,n=30). Group B was treated with phenobarbital tablets plus carbamazepine tablets, and group A was given LEV tablets additionally. After 6 month treatment, the clinical curative effect, cognitive function, quality of life and adverse drug reactions were compared between the two groups. Results: After the treatment, the total effective rate at the 12th and 24th week in the group A was significantly higher than that in the group B (P<0.05). The MoCA scores and SF 36 scores in the group A were much better than those in the group B (P<0.05). There was no significant difference in adverse drug reactions between the two groups (P>0.05). Conclusion:Routine medicine combined with LEV in the treatment of refractory partial epilepsy in young patients shows definite curative effect and positive significance for the promotion of cognitive function, which is worthy of clinical promotion. |
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