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| 布地奈德联合常规治疗慢性阻塞性肺疾病急性加重患者观察 |
| Observation of Effect on the Treatment of Budesonide in Chronic Obstructive Pulmonary Disease Patients with Acute Exacerbation |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 急性加重期 布地奈德 泼尼松 |
| 英文关键词:Chronic obstructive pulmonary disease Acute exacerbation Budesonide Prednisone |
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| 中文摘要: |
| 摘 要 目的:观察布地奈德联合常规治疗慢性阻塞性肺疾病急性加重（AECOPD）患者的临床疗效及安全性。方法：64例AECOPD患者随机分为3组，对照组20例采用常规治疗，布地奈德组22例在常规治疗基础上加用布地奈德2 mg雾化吸入tid，泼尼松组22例在常规治疗基础上加用泼尼松片30 mg，po qd；均连续治疗7 d。比较3组患者治疗前和治疗后24 h、72 h及7 d的1s用力呼气容积(FEV1)值、呼吸困难评分和动脉血气分析变化情况，以及3组药品不良反应发生情况。结果：治疗后72 h和7 d，布地奈德组和泼尼松组患者的FEV1值和PaO2值均明显高于对照组患者，呼吸困难评分和PaCO2均明显低于对照组患者（P<0.05）；治疗后7 d泼尼松组患者PaCO2值明显低于布地奈德组（P<0.05）。3组患者药品不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：布地奈德联合常规治疗治疗AECOPD患者可明显改善患者呼吸状况，治疗效果与泼尼松相当。 |
| 英文摘要: |
| ABSTRACT Objective:To observe the effect of budesonide in chronic obstructive pulmonary disease patients with acute exacerbation（AECOPD）.Methods: 64 cases of AECOPD patients were randomly divided into three groups.The control group (20 cases) were treated with conventional treatment，the budesonide group(22 cases) were treated with budesonide 2 mg，inhalation，tid combined with conventional treatment，while the prednisone group(22 cases) were treated with prednisone tablets 10mg，po tid combined with conventional treatment.All the groups were treated 7 days. FEV1 values, dyspnea score and blood gas analysis changes of three groups were statistical analyzed pre treatment and 24 hours, 72 hours and 7 days post treatment，and the adverse drug reactions of the three groups were observed. Results:After 72 hours and seven days treatment，FEV1 values and PaO2values of the prednisone group and the budesonide group were higher than those of the control group when their dyspnea score and PaCO2 were lower 72 hours and 7 days post treatment(P<0.05).After seven days treatment，PaCO2 values results of the prednisone group were lower than those of the budesonide group 7 days post treatment(P<0.05).There were no significant difference on the incidence of adverse reactions among three groups(P＞0.05).Conclusion:Budesonide combined with conventional treatment，can significantly improve AECOPD of chronic respiratory condition of the patient.There's little difference between prednisone and budesonide and budesonide can be used for AECOPD. |
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