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| 加巴喷丁联合用药治疗带状疱疹后神经痛伴焦虑患者的疗效观察 |
| Clinical Efficacy of Gabapentin Capsules in the Treatment of PHN Patients with Anxiety |
| 投稿时间：2014-09-24 修订日期：2014-12-06 |
| DOI： |
| 中文关键词: 加巴喷丁 阿米替林 曲马多 带状疱疹后神经痛 焦虑 |
| 英文关键词:Gabapentin capsules (GBP) Amitriptyline Tramadol Postherpetic neuralgia (PHN) Anxiety |
| 基金项目:浙江省医学会临床科研基金项目（编号:2012ZYC-A108） |
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| 中文摘要: |
| 摘 要 目的： 探讨加巴喷丁(GBP）联合阿米替林、曲马多治疗带状疱疹后神经痛(PHN)伴焦虑患者的临床效果。方法: 选择伴不同程度焦虑症状的PHN患者106例，随机分为观察组和对照组各53例，观察组给予GBP胶囊联合阿米替林片、曲马多缓释片；对照组单用GBP胶囊治疗，分别于用药前、用药后第1周、第4周对患者焦虑、抑郁状态，生活质量以及镇痛程度进行VAS评分，评价临床治疗效果。结果: 用药第1周和第4周开始，两组焦虑状态、抑郁状态评分，生活质量以及VAS评分均较治疗前明显降低（P<0.05），且观察组评分较对照组下降更为显著（P<0.05）。观察组不良反应发生率明显低于对照组（P<0.05）。结论: GBP联合曲马多、阿米替林治疗PHN伴焦虑的患者，能有效降低患者的VAS评分，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of gabapentin capsules (GBP) combined with amitriptyline and tramadol in the treatment of patients with postherpetic neuralgia (PHN) and anxiety. Methods: Totally 106 PHN patients with anxiety symptoms at different degree were selected and divided into group A (n=53) and group B (n=53). Group A was given GBP, amitriptyline and tramadol, while group was given GBP only. The anxiety, depression, quality of life and pain relieving intensity (by VAS) of the patients were determined before the medication (T1) and in the first week (T2) and the fourth week (T3) after the medication. Follow up was carried out regularly according to the requirements to evaluate the clinical efficacy.Results: The anxiety, depression and VAS scores in the two groups on T2 were statistically significant lower than the corresponding results on T1 (P<0.05). On T3, however, there were statistically significant differences between the two groups (P<0.05). The total adverse reaction rate of group A was significantly lower than that of group B (P<0.05). The total effective rate of group A was significantly higher than that of group B (P<0.05). Conclusion:GBP combined with tramadol and amitriptyline in the treatment of PHN patients with anxiety can effectively control the pain of the patients, significantly reduce the scores of VAS and improve the quality of life of the patients. |
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