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| 草黄乌头二萜生物碱成分研究 |
| Study on Diterpenoid Alkaloids from the Roots of Aconitum Straminiflorum |
| 投稿时间：2014-11-04 修订日期：2014-12-12 |
| DOI： |
| 中文关键词: 草黄乌头 毛茛科 二萜生物碱 |
| 英文关键词:Aconitum straminiflorum Ranunculaceae Diterpenoid alkaloids |
| 基金项目:国家自然科学基金项目（编号：21362045）；云南省社会发展科技计划项目(编号：2012CG007） |
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| 中文摘要: |
| 摘 要 目的： 对毛茛科乌头属植物草黄乌头的块根进行化学成分研究。方法: 草黄乌头的干燥块根用90%乙醇回流提取，所得浸膏用1.5% HCl溶解，氯仿萃取，酸水溶液用25% 氨水调至pH为9，氯仿萃取，得总生物碱粗提物。粗提物通过各种柱色谱分离纯化，经光谱数据 (1H-NMR，13C-NMR，MS) 进行结构鉴定。结果:分离得到7个二萜生物碱，分别鉴定为：阿克诺辛（aconosine, 1），13-去氧卢乌碱（13-deoxyludaconitine, 2），嘟拉碱（dolaconine, 3），ezochasmanine（4），塔拉萨敏（talatisamine, 5），鹤乌碱（scopaline, 6），卡马乌头原碱（cammaconine, 7）。结论: 首次对草黄乌头进行化学成分研究，化合物1 7为首次从草黄乌头中分离得到。 |
| 英文摘要: |
| ABSTRACT Objective: To study the chemical constituents of Aconitum straminiflorum. Methods: The air dried roots of A. straminiflorum were powdered and extracted three times with 90% ethonal under reflux. After the removal of the solvent under reduced pressure, the crude extract was dissolved in 1.5% HCl solution (7 L). The acidic solution was basified to pH 9.0 with ammonia (25%) and extracted with CHCl3 to obtain crude extract of total alkaloids after the removal of CHCl3. The compounds were isolated and purified by column chromatography and identified based on spectral analysis (MS, 1H-NMR and 13C-NMR). Results: Totally 7 compounds were isolated from A. straminiflorum, and characterized as aconosine (1), 13 deoxyludaconitine (2), dolaconine (3), ezochasmanine (4), talatisamine (5), scopaline (6) and cammaconine (7), respectively. Conclusion:Seven diterpenoid alkaloids are isolated from A. Straminiflorum for the first time. |
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