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| 环吡酮胺阴道栓联合氟康唑治疗外阴阴道假丝酵母菌的疗效观察 |
| Efficacy of Ciclopirox Olamine Vaginal Suppositories Combined with Fluconazole in the Treatment of Vulvovaginal Candidiasis |
| 投稿时间：2014-09-16 修订日期：2015-01-20 |
| DOI： |
| 中文关键词: 环吡酮胺阴道栓 氟康唑 特比萘芬阴道泡腾片 外阴阴道假丝酵母菌 |
| 英文关键词:Ciclopirox vaginal suppositories Fluconazole Terbinafine vaginal effervescent tablets Vulvovaginal candidiasis |
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| 中文摘要: |
| 摘 要 目的： 观察环吡酮胺阴道栓联合氟康唑治疗外阴阴道假丝酵母菌的疗效观察。方法: 74例外阴阴道假丝酵母菌（VVC）感染患者随机分为两组各37例。对照组给予口服氟康唑联合阴道内放置盐酸特比萘芬阴道泡腾片，观察组给予口服氟康唑联合环吡酮胺阴道栓治疗，观察对比两组近期（7 d）、远期（1、3个月）的临床疗效及用药安全性。结果:治疗7 d后，两组临床总有效率差异无统计学意义（P>0.05）；1个月后随访，两组复发率比较，差异无统计学意义（P>0.05），3个月后随访，观察组复发率为2.7%，明显低于对照组的22.2%（P<0.05）。两组均未发生严重药物不良反应。结论: 口服氟康唑联合环吡酮胺阴道栓治疗外阴阴道假丝酵母菌疗效确切，可明显降低复发率，且用药安全,无严重不良反应。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of ciclopirox olamine vaginal suppositories combined with fluconazole in the treatment of vulvovaginal candidasis. Methods: Totally 74 cases of vulvovaginal candidasis (VVC) infection were randomly divided into two groups with 37 ones in each. The control group orally received fluconazole combined with terbinafine hydrochloride vaginal effervescent tablets, and the observation group orally received fluconazole combined with ciclopirox olamine vaginal suppositories. The recent (7 days) and long term (1 and 3 months) clinical curative effects and the drug safety in the two groups were observed and compared.Results: after the 7 day treatment, the total clinical effective rate of the two groups showed no significant difference (P>0.05); after the 1 month follow up, the recurrence rate of the two groups had no significant difference (P>0.05); after the 3 month follow up, the recurrence rate of the observation group (2.7%) was significantly lower than that of the control group (22.2%, P<0.05). The two groups showed no serious adverse drug reactions. Conclusion:Fluconazole combined with ciclopirox olamine vaginal suppositories in the treatment of vulvovaginal candidasis exhibits promising curative effect and low recurrence rate without serious adverse reactions. |
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