| ABSTRACT Objective:To study the Staphylococcus aureus colonization in the skin lesions of patients with atopic dermatitis and its drug sensitivity, and to provide research basis for the anti infection treatment of the disease. Methods:136 patients with atopic dermatitis were selected as observation group and 93 physical health persons as control group. The pathogenic bacteria distributions of skin lesions of observation group, non lesion site of observation group and control group were detected, the drug sensitivity of Staphylococcus aureus was detected in skin lesions, and the correlation between EASI score and colony density was observed.Results:The positive rate of pathogenic bacteria in skin lesions of observation group was 75.74%, which was higher than that in non lesion site of observation group and control group (P<0.01); the positive rate of pathogenic bacteria in non lesion site of observation group was higher than that in control group (P<0.01). The highest detection rate of pathogenic bacteria was gram positive bacteria, and the detection rates of Staphylococcus aureus were highest in the lesions in skin lesions and non lesion site of observation group. EASI score was positively correlated with colony density (r=0.631, P<0.05). In the 85 strains of Staphylococcus aureus detected in skin lesions of observation group, the detection rate of MRSA was 30.59%; the susceptibility rates of MSSA and MRSA to levofloxacin, vancomycin and teicoplanin were 100.00%; the sensitivity rates of MSSA to cefotaxime, cefazolin, cefoxitin, rifampin, azithromycin, clindamycin, sulfamethoxazole / trimethoprim were significantly higher than those of MRSA (P<0.05 or P<0.01). Conclusion:Staphylococcus aureus colonization in the skin lesions of patients with atopic dermatitis was common, and antibiotics should be used reasonably according to the results of drug sensitivity. |
