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| 血容量扩充药及其临床应用 |
| Plasma Volume Extender and its Clinical Application |
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| DOI： |
| 中文关键词: 血容量扩充药 临床应用 合理用药 人血白蛋白 不良反应 血定安 贺斯 血浆代用品 |
| 英文关键词:Plasma,Volume extender,Seroalbumine Humane,Gelofusine,Haes steril,Dextram,Hydroxyethyl starch |
| 基金项目: |
| 郭代红 崔巍 孟潇 |
| [1]解放军总医院第一临床药局北京100853 [2]北京大学药学院99级实践生 |
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| 中文摘要: |
| 目的：综述血容量扩充药的临床合理选药用药。方法：通过检索中英文相关文献，从有效、安全、经济三方面对血容量扩充药各主要品种进行分析。结果：从药效、不良反应和成本支出综合考虑，右旋糖酐40及706代血浆以价格优势保证较高的应用量。但有较高的不良反应发生率；血定安和贺斯的成本效果较为适中；人血白蛋白因其高昂的价格，及其血液制品的潜在危险性，并非扩充血容量的最佳选择。结论：血容量扩充药应用日益增多，需从有效、安全、经济综合考虑，合理选用。 |
| 英文摘要: |
| Objective: To review the rational selection and utilization of plasma volume extender in clinical application.Method: The efficacy, safety and economy of main kinds of plasma volume extender were analyzed through indexing its English and Chinese documents concerned.Result: Dextram 40 and Hydroxyethyl starch have been maintaining their high utilization due to their dominance in price despite higher rates of ADRs; the cost effectiveness of Gelofusine and Haes steril is appropriate considering their general consulting potency, DR reports and cost expenditure; seroalbumine humane is not the optimum selection because of its expensive price and potential hazards as blood products.Conclusion: Considered to be effective, safe and economical, the plasma volume extender should be rationally administrated because of its more and more application. |
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