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| 阿奇霉素、红霉素治疗下呼吸道感染综合评价 |
| Evaluation of Efficacy and Safety of Intravenous Azithromycin and Erythromycin in the Treatment of Lower Respiratory Tract Infections |
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| DOI： |
| 中文关键词: 阿奇霉素 红霉素 联合治疗 下呼吸道感染 药物不良反应 成本-效果分析法 层次分析法 |
| 英文关键词:Azithromycin,Erythromycin,Synthetic evaluation,Clinical study,Adverse Drug Reaction,Cost effectiveness analysis(CEA),Analytic hierarchy process(AHP) |
| 基金项目:深圳市卫生科技计划项目 (2 0 0 0 0 60 18) |
| 李东 |
| 深圳市人民医院临床药学研究室 广东深圳518020 |
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| 中文摘要: |
| 目的 :建立注射用阿奇霉素与红霉素治疗下呼吸道细菌感染的综合评价方法。方法 :采用随机对照多中心分组研究 ,观察临床疗效和药物不良反应 ,用成本 效果分析法分析阿奇霉素和红霉素的经济性 ,用层次分析法评价两药的综合效果。结果 :两药评价权重分别为 0 .75 986 8,0 .2 4 0 132 ,药物疗效、成本 效果比和药物不良反应的评价权重分别为 0 .5 716 2 6 ,0 .2 4 0 919,0 .1874 5 5 ,通过一次性检验 (CI <0 .1,CR <0 .1) ;其综合评价值分别为 78.71,2 1.2 9。结论 :阿奇霉素的综合评价效果明显优于红霉素。 |
| 英文摘要: |
| Objective: To evaluate the clinical efficacy, safety and economic issues of intravenous azithromycin and erythromycin respectively in the treatment of lower respiratory tract infections.Method: The efficacy and adverse reactions of azithromycin and erythromycin were observed in the treatment of lower respiratory tract infections by a randomized, controlled, multi center study, the economic issues of azithromycin and erythromycin were respectively analyzed by means of cost effectiveness and the comprehensive efficacy of azithromycin and erythromycin were evaluated by means of the Analytic Hierarchy Process(AHP).Result: The evaluation weights of azithromycin and erythromycin are 0.759 868 and 0.240 132 respectively; and the evaluation weights of efficacy, cost effectiveness ratio and adverse reactions are 0.571 626, 0.240 919 and 0.187 455 respectively. The identical test was qualified(CI< 0.1 , CR< 0.1 ; the comprehensive evaluation weights of azithromycin and erythromycin are 78.71 and 21.29 respectively.Conclusion: The comprehensive evaluation weight of azithromycin is better than erythromycin's. |
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