| Objective: To enhance the understanding of drug hepatitis by analyzing the etiology and clinical features of 136 cases with drug-induced liver disease.Method: 136 cases with drug-induced liver damage admitted to our hospital from 19992004 were reviewed according to their drug histories, clinical features, liver function tests and serum markers and responses to withdrawal.Result: The etiological drugs were herbal medicine (a(c)28.68%), anti-tuberculosis drugs (a(c)27.21%aa), antia2thyroid agent (a(c)10.29%aa), and anti-infectious drugs (a(c)5.88%), and also included antia2tumor agents (a(c)3.60%), anti-psychotic drugs (a(c)3.60%), and so on. Most of the drug hepatitis appeared during the first month to the second month of the treatment. Patients with HBSAg positive were at a higher risk of drug hepatitis,even severe hepatitis.Conclusion: Conclusion The factors to influence drug hepatitis include the kinds of drugs to be used,duration of drugs used,combined use of drugs,health condition,etc. |
