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| 盐酸奈福泮复合芬太尼用于术后镇痛临床疗效 |
| Clinical Efficacy of Nefopam Used with Fentanyl in Patient-control Analgesia after Pulmonary Lobectomy |
| 投稿时间：2005-07-27 修订日期：2005-08-08 |
| DOI： |
| 中文关键词: 奈福泮 芬太尼 自控镇痛 |
| 英文关键词:Nefopam Fentanyl Patient-control analgesia |
| 基金项目: |
| 陈振毅 于忠元 黄曦 |
| 福建医科大学附属厦门市第一医院麻醉科,福建厦门361001 |
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| 中文摘要: |
| 目的：评价盐酸奈福泮联合芬太尼用于肺叶切除术患者静脉自控性镇痛（PCA）的有效性及安全性.方法：80例全麻下行肺叶切除术患者,随机分为芬太尼组（Ⅰ组）和奈福泮复合芬太尼联合用药组（Ⅱ组）各40例,行术后PCA.采用双盲法研究.观察术后10 min,2,4,8,16,24,48 h各时点VAS评分,记录出现的不良反应.结果：Ⅱ组早期镇痛效果好于Ⅰ组,两组在8h后VAS评分差异不明显,P＞0.05.Ⅱ组恶心、呕吐发生率明显低于I组,出汗发生率明显高于Ⅰ组（P＜0.01）.结论：盐酸奈福泮复合芬太尼用于术后PCA,可减少芬太尼的用量,镇痛效果满意,不良反应低,可作为术后镇痛的较佳配药选择. |
| 英文摘要: |
| Objective; To evaluate the efficacy and safety of nefopam with fentanyl used in patient-control analgesia (PCA) after pulmonary lobectomy. Method: 80 patients undergoing pulmonary lobectomy under general anesthesia were randomly divided into nefopam plus fentanyl group( Group A) and fentanyl group( Group B) for double - blind study of the effect of postoperative analgesia. The visual analogue score (VAS) was observed at lOmin, 2, 4, 8, 16, 24, 48 h after PCA was initiated. The adverse reactions were also recorded. Result; The VAS of Group A was significantly less than that of Group B, and there was no significant statistical difference of VAS in both groups. The incidence of nausea and vomiting in Group A was lower than that in Group B, and sweating was more in Group A than Group B. Conclusion: PCA initiated by nefopam plus fentanyl may signicantly reduce the dose of fentanyl and be characterized by the analgesia effect and fewer side effects, so it may be one of the prior choices in the postoperative analgesia. |
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