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| 基于药品不良反应数据库的配对病例对照研究 |
| A Matched Case-control Study Based on the Database of Adverse Drug Reaction |
| 投稿时间：2005-06-14 修订日期：2005-08-12 |
| DOI： |
| 中文关键词: 药品不良反应 病例对照研究 药物不良反应自发报告 |
| 英文关键词:Adverse drug reaction Database Case-control study |
| 基金项目: |
| 王越 徐厚明 孙骏 |
| [1]中国药科大学,南京210009 [2]江苏省药品不良反应监测中心,南京210009 |
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| 中文摘要: |
| 目的：研究利用药品不良反应数据库开展病例对照研究的方法.方法：从药品不良反应数据库中提取2003年11月17日～2005年5月14日发生过敏性休克的病例为病例组,以性别、年龄、地区为配对条件在同一时间内提取其他病例作为对照,进行配对病例对照研究.结果：过敏性休克发生的危险因素有：合并用药、静脉给药、左氧氟沙星、青霉素.结论：通过这种方法可以及时对病因假设进行初步验证,同时也为基于药品不良反应数据库开展相关研究提供了一种新思路. |
| 英文摘要: |
| Objective: To establish a way to case-control study based on the database of adverse drug reaction. Method: Some irritable shock cases were selected as the case group in database from November 17,2003 to May 14,2005 and at the same time, some other cases were selected as the control group in line sex, age and region. Then a pair -matched case - control study was conducted. Result: Combination of other drugs, administration of drugs by vein levofloxacin and penicillin would be the dangerous factors in the occurrence of irritability shock. Conclusion: In this way we can timely validate a pathogenic hypothesis and find a new way for developing the study that is based on the database. |
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