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| 谷胱甘肽对胆道感染伴肝功能损害的临床试验 |
| Clinical Effects of Reduced Glutathione on the Liver Dysfunction Induced by Infection of the Bile Duct |
| 投稿时间：2005-06-14 修订日期：2005-08-05 |
| DOI： |
| 中文关键词: 谷胱甘肽 胆道感染 肝损害 随机临床试验 |
| 英文关键词:Glutathione(GSH),Infection of bile duct,Liver dysfunction,Randomized clinioal trial (RCT) |
| 基金项目: |
| 胡蓉 盛宇伟 周予民 |
| [1]上海第一人民医院宝山分院药剂科,上海200940 [2]上海第一人民医院宝山分院外科,上海200940 |
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| 中文摘要: |
| 目的：探讨还原性谷胱甘肽（GSH）对胆道感染伴肝功能损害的治疗作用。方法：将胆道感染伴肝功能损害的50例，随机分为两组。对照组25例，ATP 40mg，ivd，肌苷2．0g，维生素C 2．0g，qd，连用7d。治疗组25例，在上述治疗的基础上加用GSH 1．8g，连用7d，同时监测肝功能：谷丙转氨酶（ALT），天冬氨酸转氨酶（AST），总胆红素（TBL）并进行比较。结果：治疗组较对照组术后1周肝功能恢复良好，黄疸消退更早，酶谱恢复正常，显效率分别为72．0％（18／25）和40．0％（10／25），总有效率分别为92．0％（23／25）和64.0％（16／25），两组比较差异有统计学意义（P〈0．05）。结论：GSH治疗胆道感染伴肝功能损害起效迅速，疗效确切，有重要的临床应用价值。 |
| 英文摘要: |
| Objective: To evaluate the clinical effect of reduced glutathione on the liver dysfunction induced by infection of the bile duct. Method: 50 patients with liver dysfunction induced by infection of bile duct were randomly divided into 2 groups. The control group received ATP 40mg; inosine 2. 0 g, vitamin C 2. 0 g every day through intravenous injection for 7 days. Besides these treatments, the GSH group was treated with GSH 1.8 g per day for 7 days. At the same time the major biochemical (ALT, AST, TBL) parameters were measured. Result: ALT, AST and TBL showed some differences in the two groups. The GSH in the treatment group (the efficacy rate being 92.0%) was better than the drugs in the control group (the efficacy rate being 64.0% ) ( P < 0.05 ). Conclusion: GSH is a rapid and effective drug in treating the liver dysfunction induced by infection of the bile duct. |
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