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| 贞芪扶正胶囊配合化疗治疗晚期恶性肿瘤临床观察 |
| Clinical Observation of the Treatment of Advanced Cancer with Zhenqi Fuzheng Capsules in the Combination of Chemotherapy |
| 投稿时间：2005-09-27 修订日期：2005-10-27 |
| DOI： |
| 中文关键词: 贞芪扶正胶囊 行为状态评分 细胞免疫 化学治疗 肿瘤 恶性 |
| 英文关键词:Zhenqi Fuzheng capsules KPS scale Cytoimmunity Chemotherapy Cancer |
| 基金项目: |
| 刘素勤 孙亮新 班丽英 周涛 |
| 大连医科大学附属第一医院肿瘤科,辽宁大连116011 |
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| 中文摘要: |
| 目的：观察贞芪扶正胶囊配合化疗治疗晚期恶性肿瘤的疗效、不良反应、KPS评分及细胞免疫功能变化。方法：观察组患者100例,予贞芪扶正胶囊4粒，bid，po，于化疗前3d开始至化疗2周期结束后7d为1疗程：对照组50例只给予化疗。观察疗效、毒副反应、KPS评分及细胞免疫功能变化。结果：两组化疗疗效无差异：观察组出现WBC减少少于对照组（61．0％vs78．0％），化疗后KPS评分上升，CD4／CD8比值、NK阳性细胞百分率化疗后提高，差异显著（P〈0．05）。结论：贞芪扶正胶囊配合化疗治疗晚期恶性肿瘤，WBC减少发生率低，可提高患者KPS评分及细胞免疫功能，宜作为化疗的常规辅助中药用药。 |
| 英文摘要: |
| Objective: To evaluate the clinical efficacy, side effect, KPS scale and cytoimmunity function of Zhenqi Fuzheng capsules in the combination of chemotherapy in the treatment of advanced cancer. Method: 100 patients received Zhenqi Fuzheng capsules 4#, bid, po and chemotherapy for 2 courses. Fifty patients received chemotherapy as control group. Result: The overall response rates were 38.0% vs 34.0% , and the occurrence of leucopenia was 61.0% vs 78. 0% (P <0. 05 ) , the improvement of KPS scale and both CD4/CD8 and NK ratio was observed in Zhenqi Fuzheng capsules group (P <0. 05). Conclusion: Zhenqi Fuzheng capsules can decrease the occurrence of leucopenia and improve the KPS scale and cytoimmunity function in the period of chemotherapy. |
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