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| 抗结核药物使用调查分析 |
| Analysis of the Medication of Antituberculosis Drugs |
| 投稿时间：2005-09-28 修订日期：2005-12-01 |
| DOI： |
| 中文关键词: 抗结核药物 限定日剂量 药物利用 |
| 英文关键词:Antituberculosis drugs Defined Daily Dose Drug utilization |
| 基金项目: |
| 温筱煦 冯端浩 阎锋 李俊山 |
| 解放军总医院第二附属医院,北京100091 |
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| 中文摘要: |
| 目的：分析住院结核病患者药物使用数据，为临床用药提供参考。方法捕l用医院信息系统数据库。统计2002—2004年2873名住院结核病患者抗结核药物使用数据，分析药物临床使用情况。结果：根据DDDs排序，异烟肼、利福平、吡嗪酰胺、乙胺丁醇和链霉素仍然是抗结核化疗的首选药物；利福霉素类药物使用较广泛；喹诺酮类药物在治疗耐多药结核病方面前景很好，但其高成本影响了该类药物的用药频度；联合用药方案以四联为主，符合WHO推荐的治疗原则。结论：主要抗结核药物的利用情况基本合理，在引入新药时需要考虑耐药性、经济因素和患者的依从性。 |
| 英文摘要: |
| Objective: To provide reference for clinical medication by analyzing medication data of tuberculosis inpatients in the years of 2002 and 2004. Method: Data of more than 2000 inpatients about their use of antituberculosis drugs were collected by use of the hospital information system database, and their clinical medication was analyzed with Defined Daily Dose(DDD) method. Result: According to DDDs sort order, INK, RFP, PZA, EMB and SM were still the preferable drugs for antituberculosis chemotherapy. Rifamycin drugs were more comprehensively used. Quinolones were good at MDR - TB treatment, but their high costs limited their medication frequencies; The drug combinations in four a-gents in most treatments were in compliance with the treatment principle suggested by WHO. Conclusion: The utilization of major antituberculosis drugs is basically rational, and drug resistance, economic factors and patient compliance should be considered when new drugs are introduced. |
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