| Objective:To select a best therapeutic scheme for retreating multi-drug resistant pulmonary tuber-culssosis among the four kinds of fluoroquinolones:Ciprofloxacin(C) , Ofloxacin(O) , Levofloxacin( V) , and Sparfloxacin ( Sp). Method: According to the principle of pharmacoeconomics, using cost-effectiveness analysis (CEA) , the assessment and survey of the influencing factors (price) were carried out, and at the same time, a sensitive analysis was performed. Result:In the comparison of the sputum negative conversion rate, the bacteria rate of group O was similar to that of group C(P>0.05). Group V resembled group Sp(P>0.05);Group V and group Sp dwarfed group C and group O respectively (P > 0.05). There was no statistical significance in the effect rates of X-ray examined focus or closure rates of cavities in the research groups (P>0.05); There was no statistical significance in the rate of adverse reactions (P >0.05). There were significant differences in cost among the four groups. Conclusion:Levofloxacin is the most effective and inexpensive scheme. The result of the sensitive analysis is in keeping with that of CEA, which indicates the credibility of CEA. |
