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| 环孢素A血药浓度影响因素综述 |
| Factors Influencing the Serum Concentration of Cyclosporine A |
| 投稿时间：2005-10-10 |
| DOI： |
| 中文关键词: 环孢素 血药浓度 影响因素 综述 |
| 英文关键词:Cyclospfine A Serum drug concentration Influencing factor |
| 基金项目: |
| 万元胜 师少军 吴伶 陈华庭 |
| [1]华中科技大学同济医学院附属协和医院药剂科,武汉430022 [2]华中科技大学同济医学院附属协和医院儿科,武汉430022 |
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| 中文摘要: |
| 目的：探索影响环孢素A（CsA）血药浓度的因素，为临床合理用药提供参考。方法：以已有国内外材料为基础，进行分析和归纳。结果：移植器官、肝功能、胃肠道功能、血红细胞数量、术后时间、食物与饮料、给药方法、药物剂型和质量、合并用药等均为影响CsA血药浓度的因素。结论：鉴于CsA治疗窗较窄，个体差异较大，影响CsA血药浓度的因素很多，建议临床应用CsA时应该结合患者实际情况定期进行血药浓度监测，及时调整用药方案，以确保患者的用药安全、有效。 |
| 英文摘要: |
| Objective: To observe the factors that influence the serum concentration of cyclosprine A (CsA ) and to offer reference to the rational use of drugs. Method: The present domestic and international materials were analyzed and summed up. Result: These influencing factors included transplanted organs, functions of liver and gastrointestinal tract, quantity of red blood cell, post- transplant days, food and beverage, methods of administration, dosage forms and quality of drug and combining use of drugs. Conclusion: According to patients'actual conditions, doctors should regularly carry on therapeutic drug monitoring, adjust the scheme of using medicine in time and ensure the patients in their safe and effective use of drug. |
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