|
| 伊立替康联合5-FU/CF治疗转移性结直肠癌46例 |
| Irirotecan Combined with Fluoropyrimidine in the Treatment of 46 Cases with Metastatic Colorectal Carcinoma |
| 投稿时间：2006-10-08 修订日期：2006-12-11 |
| DOI： |
| 中文关键词: 伊立替康 氟尿嘧啶 四氢叶酸 转移性结直肠癌 化疗 |
| 英文关键词:Irirotecan Fluoropyrimidine Tetrahydrofolate Metastatic colorectal cancer Chemical therapy |
| 基金项目: |
| 邓颖 杨兰 潘海霞 胡洪林 任刚 敖睿 |
| 四川省人民医院肿瘤科,成都610071 |
| 摘要点击次数: 2666 |
| 全文下载次数: 101 |
| 中文摘要: |
| 目的：评价伊立替康（CPT—11）联合5-FU／CF方案治疗FOLFOX4或LV5FU2方案失败的结直肠癌的客观疗效，临床受益和不良反应。方法：用CPT—11联合5-FU／CF方案治疗晚期结直肠癌患者46例，采用2周方案，即CPT—11 180mg／m^2 iv d1，CF200mg／m^2 iv d1-2，5-FU400mg iv bolusd1，5-FU600mg／m^2 iv，22hd1—2，每2周重复。观察期3—6个月。结果：完全缓解0例，部分缓解18例（有效率39．13％），稳定20例（43．47％），进展8例（17．39％）。临床受益率82．6％（19／23）。临床反应评价有效者36例（78．86％），生活质量显著提高。结论：CPT-11联合5-Fu／CF方案可作为转移性结直肠癌的二线治疗。 |
| 英文摘要: |
| Objective:To evaluate the efficacy and toxicity of Irirotecan(CPT-11) combined with 5-FU/CF in the treatment of metastatic colorectal cancer, in which FOLFOX4 or LV5FU2 had failed to cure it. Method: 46 cases of metastatic colorectal cancer patients were treated by CPT-11 combined with 5-FU/CF for one cycle every two weeks; namely, CPT-11 was given by 180mg/m2 iv d1, CF by 200mg/m2 iv d1-2, 5-FU by 400mg iv bolus d1, and 5-FU by 600mg/m2 iv 22h d1-2. Two weeks was a cycle. The study term was 3-6 months. Result:CR was 0, PR was 39. 13% (18/46) , SD was 43.47% (20/46) , PD was 17.39% (8/46) and CBR was 82.69% (38/46). The clinical reaction evaluation efficiency was 78. 86% (36/46). Their life quality was notably improved. Conclusion:CPT-11 combined 5-Fu/CF can be used as second-line treatment for metastatic colotedal cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
