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| 阿卡波糖联合不同胰岛素控制血糖疗效比较 |
| Comparisons of Therapeutic Effects of Blood Glucose Control by Using Acarbose in Combination with Different Insulin |
| 投稿时间：2006-11-28 修订日期：2007-01-26 |
| DOI： |
| 中文关键词: 阿卡波糖 甘精胰岛素 精蛋白胰岛素 血糖 |
| 英文关键词:Acarbose,Insulin glargine,Human NPH insulin,Blood glucose |
| 基金项目: |
| 梁力晖 王敏 李华珠 |
| 湖南省人民医院内分泌科 长沙410002 |
| 摘要点击次数: 1531 |
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| 中文摘要: |
| 目的:观察阿卡波糖分别与甘精胰岛素及精蛋白胰岛素联合控制血糖之疗效。方法:将58例患者随机分为甘精胰岛素组或人精蛋白(NPH)胰岛素组,于睡前皮下注射胰岛素并联合阿卡波糖治疗3周,观察试验终点时两组间的血糖控制情况、胰岛素用量及低血糖事件。结果:两组的空腹血糖平稳,治疗终点时甘精胰岛素组全天各时点血糖均值低于精蛋白胰岛素组,尤以晚餐后血糖与精蛋白胰岛素组相差最大,早中餐后2h血糖差异无统计学意义。结论:阿卡波糖联合甘精胰岛素或精蛋白胰岛素对控制2型糖尿病患者,24h总体血糖的稳态有效,低血糖发生率低,阿卡波糖联合甘精胰岛素疗效更优。 |
| 英文摘要: |
| Objective:To observe therapeutic effects of blood glucose control by using acarbose in combination with different insulin.Method:58 patients were randomly divided into two groups treated with either insulin glargine (Lan- tus;Aventis) or human NPH insulin (Novolin;NovoNordisk).Subcutaneous injection of insulin before sleep and oral acar- bose were carried out for the treatment,which lasted three weeks.The degree of blood control,the amount of insulin used, and the cases of hypoglycemia for both groups were observed at the end of the experiments.Result:The fasting blood glu- cose showed its normal and stable result,and the average blood glucose values at different time slots per day in the group treated with insulin glarglne were lower than those in the group treated with human NPH insulin.The maximum difference of blood glucose values occurred after dinner while no significant variance appeared after breakfast and after lunch.Conclu- sion:The therapeutic effects are quite efficient and stable in controlling 24-hour blood glucose in type 2 diabetes by using acarbose in combination with either insulin glargine or human NPH insulin (Novolin;NovoNordisk).In addition,the oc- currence rates of hypoglycemia with both methods are low whereas the therapeutic effects for the first group are superior to those for the latter group. |
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