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| 丙硫氧嘧啶引起肝损害的调查和分析 |
| Retrospective Investigation of Liver Damage Caused by Propylthiouracil in the Treatment of Hyperthyroidism |
| 投稿时间：2006-07-04 修订日期：2006-11-22 |
| DOI： |
| 中文关键词: 丙硫氧嘧啶 肝损害 药物不良反应 |
| 英文关键词:Propyhhiouracil,Liver damage,Adverse drug reoction |
| 基金项目: |
| 管秀玲 |
| 台州市第一人民医院 浙江台州318020 |
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| 中文摘要: |
| 目的:探讨丙硫氧嘧啶治疗甲状腺机能亢进(甲亢)过程中引起肝损害的发生率、特点及相关因素。方法:对我院确诊为甲亢并使用丙硫氧嘧啶治疗的106例患者的肝损害发生情况,进行回顾性调查分析。结果:106例服用丙硫氧嘧啶导致肝损害的发生率为28.30%(30例),其中亚临床性肝损伤的发生率为16.98%(18例),症状性肝损害的发生率为11.32%(12例),肝损害最多出现在服药后2个月内(96.67%),肝损害时丙硫氧嘧啶服用剂量为150～300mg·d~(-1)。结论:丙硫氧嘧啶引起的肝损伤,多发生在治疗的初始阶段,临床过程相对良性,停药、保肝和对症治疗后,肝功能可恢复正常。 |
| 英文摘要: |
| Objective:To discuss the incidence,characteristics and related factors of liver damage caused by pro- pylthiouracil in the treatment of hyperthyroidism.Method:A retrospective investigation was performed concerning the liver damage in 106 patients with the diagnosed hyperthyroidism treated by propylthiouracil.Result:The incidence rate of liver damage in 106 patients was 28.30% (30 cases),18(16.98%)of whom was subclinical,and 12(11.32%),symptomat- ic.Most of the liver damage(96.67%) occurred during the first two months of medication,and the dosage was 150-300 mg per day.Conclusion:The liver damage caused by propylthiouracil occurs in the early stage of medication,and the clini- cal course is comparatively good,and is reversible after proper treatments. |
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