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| 卡马西平不良反应国内文献分析 |
| Analysis of Adverse Drug Reaction of Carbamazepine Reported in Domestic Medical Journals within Past 12 Years |
| 投稿时间：2006-10-31 |
| DOI： |
| 中文关键词: 卡马西平 药物不良反应 文献分析 |
| 英文关键词:Carbamazepine,Adverse drug reaction,Literatures review |
| 基金项目: |
| 朱曼 孙艳 郭代红 张莉 |
| 解放军总医院药品保障中心 北京100853 |
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| 中文摘要: |
| 目的:探讨卡马西平不良反应发生的一般规律和临床特点。方法:对1994—2005年国内医学期刊中应用卡马西平所发生的不良反应进行统计分析。结果:卡马西平不良反应的男女性别比例为1.21:1。不良反应发生时间大多在用药1个月内;联合用药的不良反应有9例。不良反应以皮肤损害为多见,占总例次的58.29%;其次为中枢神经系统(CNS)和心血管系统的不良反应。95.07%的患者痊愈或好转,4.93%的患者死亡。结论:临床应合理应用卡马西平;重视ADR的临床监测。 |
| 英文摘要: |
| Objective:To explore the rules and characteristics of adverse drug reaction (ADR) of carbamazepine (CBZ).Method:A statistical analysis was conducted on the data of ADR from 1994 to 2005.Result:The carbamazepine ratio of male to female in the adverse drug reaction (ADR) was 1.21:1.The ADR commonly appeared within 1 month after taking the medicine.The skin injury was the most frequent,and following it were the nervous system injury and cardiovas- cular system injury.The outcome of ADR was not very bad 95.07% patients could fully recover or improve;yet,4.93% died.Conclusion:The clinical monitoring should be enhanced to make sure of the safety and rationality in the clinical CBZ application. |
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