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| 莫西沙星与左氧氟沙星治疗下呼吸道感染比较 |
| Comparative Study of Efficacy of Moxifloxaction and Levofloxaction in the Treatment of the Lower Respiratory Tract Infection |
| 投稿时间：2007-03-13 修订日期：2007-03-27 |
| DOI： |
| 中文关键词: 莫西沙星 下呼吸道感染 左氧氟沙星 |
| 英文关键词:Moxifloxaction,Lower respiratory tract inflection,Levofloxaction |
| 基金项目: |
| 徐西琳 余爱荣 |
| 广州军区武汉总医院呼吸内科，广州军区武汉总医院临床药理科 武汉430070 |
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| 中文摘要: |
| 目的:评价莫西沙星注射剂治疗下呼吸道感染的疗效及安全性。方法:将64例社区获得性肺炎(CAP)及慢性支气管炎急性发作(AECB)患者,随机分为治疗组和对照组各32例,治疗组予以莫西沙星400 mg,ivd qd;对照组给予左氧氟沙星200 mg,ivd bid,疗程均为7～14 d。结果:莫西沙星治疗组临床有效率(93.6%)虽然高于左氧氟沙星对照组(78.1%),但两组比较差异不显著,而治疗组的痊愈率(71.8%)显著高于对照组(46.9%),P<0.05;在临床症状、体征、实验室检查恢复正常方面,莫西沙星治疗组均较对照组显著减少;在细菌清除方面,尽管与左氧氟沙星比较差异不显著,但仍高于左氧氟沙星。结论:莫西沙星注射剂治疗下呼吸道感染的疗效确切,安全性好。 |
| 英文摘要: |
| Objective:To evaluate the efficacy and safety of moxifloxaction and levofloxaction in the treatment of the lower respiratory tract inflection.Method:64 cases patients were randomly divided into two groups.The clinical trial group was treated with moxifloxaction 400mg once a day,orally for 7-10 days and the controlled group treated with levo- floxaction in 200mg twice a day for 7-10 days.Result:The effective rate of the moxifloxaction group(93.9%)was high- er than that of the levofloxaction group(71.8%),but not significantly.The recovery rate of the moxifloxaction group (71.8%)was significantly higher than that of the levofloxaction group(46.9%);the days of recovery of clinical symptoms were not significantly different in the two groups.There was no significant difference between the two groups in the bacterial eradication rate.Conclusion:Moxifloxaction is effective and safe in the treatment of the lower respiratory tract inflection. |
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