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| 氟西汀与阿米替林治疗抑郁症副作用Meta分析 |
| Meta-analysis of Psychological Side Effects Induced by Fluoxetine and Amitriptyline in Treating Depression |
| 投稿时间：2007-03-30 |
| DOI： |
| 中文关键词: 抑郁症 氟西汀 阿米替林 失眠 焦虑 躁狂 Meta分析 |
| 英文关键词:Depression,Fluoxetine,Amitriptyline,Insomnia,Anxiety,Manic disorder,Meta-analysis |
| 基金项目:浙江省卫生厅医药科研基金 |
| 马永春 王佩蓉 金卫东 陈炯 王鹤秋 邢葆平 童振华 |
| 浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心，浙江省立同德医院浙江省精神卫生中心 杭州 210012，杭州 210012，杭州 210012，杭州 210012，杭州 210012，杭州 210012，杭州 210012 |
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| 中文摘要: |
| 目的:分析国内文献氟西汀与阿米替林治疗抑郁症引发失眠、焦虑、激越与躁狂的差异。方法:用关键词从中国生物医学数据库光盘检索,采用Peto固定效应模型(fixed effects model,FEM)法对符合纳入标准的氟西汀与阿米替林治疗抑郁症的随机对照研究文献中药物引发失眠、焦虑(激越)与躁狂的差异进行Meta分析。结果:15项共1205例纳入研究,其中14项报告了失眠发生率,2项研究报告焦虑(激越)发生率,5项研究报告了躁狂的发生率;氟西汀与阿米替林治疗抑郁症可出现失眠分别是21.71%和1.80%,OR_(合并)9.39(95%CI 5.37～16.44),P<0.01;引发焦虑发生率分别是6.90%和1.85%,OR_(合并)8.58(95%CI 4.90～13.60),P<0.01;引发躁狂发生率分别是2.60%和4.19%,OR_(合并)0.82(95%CI 0.51～1.30),P>0.05。结论:在治疗抑郁症中,氟西汀比阿米替林更可引发失眠、焦虑(激越),应特别加以关注。 |
| 英文摘要: |
| Objective:To compare the differences in incidences of insomnia,anxiety(irritability)and manic ep- isode induced by fluoxetine and amitriptyline in treating depression.Method:CBM discs were selected for the data sources. The rates of insomnia,anxiety(irritability)and manic episode from published clinical control trials on depression treated by fluoxetine and amitriptyline were analyzed by applying fixed effect model(FEM)of evidence-based medicine(EBM). Result:Of 1205 cases in 15 studies,the rates of insomnia induced by fluoxetine or amitriptyline were 21.71% and 1.80% ,OR 9.39(95 %CI 5.37-16.44),P<0.01;The rates of anxiety induced by fluoxetine or amitfiptyline were 6.90% and 1.85% ,OR 8.58(95 % CI 4.90-13.60),P<0.01;The rates of manic episode induced by fluoxetine or amitriptyline were 2.60% and 4.19%,OR 0.82(95 % CI 0.51-1.30),P>0.05.Conclusion:Fluoxetine induces in- somnia and anxiety(irritability)more easily than amitriptyline when treating depression. |
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