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| 含环孢素的三联免疫治疗方案对肾移植受者糖耐量的影响 |
| Effect of Cyclosporin Based Triple Immunosuppressive Therapy on Glucose Tolerance in Renal Transplant Recipients |
| 投稿时间：2007-06-20 修订日期：2007-07-16 |
| DOI： |
| 中文关键词: 肾移植后糖尿病 血糖 糖耐量减低 环孢素 泼尼松 |
| 英文关键词:Post-transplantation diabetes mellitus,Plasma glucose,Impaired glucose tolerance,Cyclosporin A,Prednisone |
| 基金项目: |
| 余爱荣 辛华雯 吴笑春 李罄 |
广州军区武汉总医院临床药理科 (武汉430070)
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| 中文摘要: |
| 目的:研究含环孢素(CsA)的三联免疫治疗方案对肾移植受者糖耐量的影响。方法:回顾性分析1996年1月-2007年5月,680例使用环孢素 泼尼松 麦考酚吗乙酯的肾移植患者的空腹血糖受损、糖耐量减低和糖尿病的发病率及影响因素。结果:空腹血糖受损、糖耐量减低和糖尿病的发病率分别为3.97%,5.15%和8.09%。糖耐量减低组和糖尿病组患者的环孢素日剂量、环孢素谷浓度和泼尼松日剂量明显高于血糖正常组。结论:环孢素给药剂量、环孢素谷浓度和泼尼松给药剂量与肾移植受者出现糖耐量减低及糖尿病密切相关。 |
| 英文摘要: |
| Objective:To study the effect of cyclosporin A based triple immunosuppressive therapy on the plasma glucose in renal transplant recipients.Method:680 renal transplant recipients treated with cyclosporine A combined with prednisone and mycophenolate mofefil from Jan.1996 to May 2007 were analysed.Result:The morbidities of impaired fast- ing glucose,impaired glucose tolerance and post-transplantation diabetes mellitus (PTDM) were 3.97%,5.15% and 8.09%,respectively.The daily doses and concentrations of CsA and the daily doses of prednisone in the impaired glucose tolerance group and PTDM group were significantly higher than those in the normal plasma glucose group.Conclusion:The daily doses and concentrations of CsA and the daily doses of prednisone were closely related to the impaired glucose toler- ance and PTDM of renal transplant recipients. |
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