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| 尼莫地平对阿尔茨海默病患者认知功能的影响 |
| Effect of Nimodipine on the Cognitive Ability of Alzheimer Disease Patients |
| 投稿时间：2007-02-27 修订日期：2007-08-30 |
| DOI： |
| 中文关键词: 尼莫地平 阿尔茨海默病 认知功能 |
| 英文关键词:Nimodipine,Alzheimer disease,Cognitive ability |
| 基金项目: |
| 江红 罗易宁 史庭慧 |
华中科技大学同济医学院附属同济医院神经科，华中科技大学同济医学院附属同济医院神经科，华中科技大学同济医学院附属同济医院神经科 (武汉 430030)
，(武汉 430030)
，(武汉 430030)
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| 中文摘要: |
| 目的:观察尼莫地平对阿尔茨海默病患者认知功能的影响并探讨其作用机制。方法:2006年1～12月来我院就诊的轻、中度阿尔茨海默病患者60例,询问病史、全面体检及影像学等检查后,随机分为尼莫地平组(口服尼莫地平30 mg,tid)和对照组(口服盐酸吡硫醇200 mg,tid),在治疗开始前和治疗后第12周分别运用简易精神状态检查量表(MMSE)和日常生活活动量表(ADL)评价患者智能状态和日常生活活动能力,并采用SPSS10.0统计软件进行统计分析。结果:应用尼莫地平12周后,患者的认知功能和日常生活能力较治疗前有明显改善,MMSE和ADL评分与对照组相比,差异具有显著性(P<0.05)。结论:尼莫地平对轻中度AD有较好的疗效,作用机制可能与其改善脑部微循环及缓解钙超载有关。 |
| 英文摘要: |
| Objective:To investigate the effect of nimodipine on the cognitive ability of the Alzheimer disease (AD) patients and to presume its mechanism.Method:60 patients with AD received their examinations and treatments in our hospital from January to December,2006.The data included the patients' disease histories,physical examinations and radiological checks.All the patients were randomly divided into two groups,Nimodipine group ( N group) and controlled group (C group).N group was given nimotop 30mg tid orally,while C group was treated with neuroxin 200mg tid.The pa- tients' cognitive and daily life abilities were accessed by MMSE and ADL in the first day and the twelfth week from the be- ginning of the treatment.All the data were analyzed by SPSS 10.0.Result:Compared with those of the controlled group, the cognitive and daily living abilities of N group patients' were improved significantly in 12 weeks after the treatment by ni- modipine (P<0.05).Conclusion:Nimodipine is safe and effective for AD.The mechanism is probably related with the improvement of cerebral microcirculation and overload of calcium. |
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