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| 拉莫三嗪治疗癫痫患者的经济学效率研究的系统评价 |
| Systemic Evaluation of the Economic Efficiency for Lamotrigine Treatment in Epilepsy Patients |
| 投稿时间：2007-03-06 修订日期：2007-07-23 |
| DOI： |
| 中文关键词: 拉莫三嗪 癫痫 药物经济学 系统评价 |
| 英文关键词:Lamotrigine,Epilepsy,Pharmacoeconomics,Systemic evaluation |
| 基金项目: |
| 杨新军 王怡 钟崇洲 郑荣远 |
温州医学院环境与公共卫生学院，温州医学院环境与公共卫生学院，温州医学院环境与公共卫生学院，温州医学院第一附属医院 (浙江温州 325000)
，(浙江温州 325000)
，(浙江温州 325000)
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| 中文摘要: |
| 目的:了解拉莫三嗪治疗不同发作类型的癫痫患者的经济学效率。方法:对最近10年MEDLINE、EMBASE和中国期刊全文期刊数据库中公开发表的药物经济学研究的原著文献进行系统评价。结果:共检索到6篇可用文献,其中成本-效用分析和成本-效果分析文献各3篇。成本-效用分析结果显示,以卡马西平为比较组,拉莫三嗪单药治疗部分发作患者,每增加一个质量调整生命年(QALY)需要的费用最少,为23344美元,加巴喷丁最高,为187857美元;以丙戊酸为比较组,拉莫三嗪单药治疗全身性发作和不能分类的发作患者,每增加一个QALY需要的费用高于托吡酯。结论:拉莫三嗪单药治疗部分发作性癫痫的增量成本-效用比优于托吡酯和加巴喷丁;而单药治疗全身性发作和不能分类发作患者劣于托吡酯。 |
| 英文摘要: |
| Objective:To evaluate the economic efficiency of lamotrigine treatment in different types of patients with epilepsy.Method:A systemic evaluation was conducted on pharmacoeconomics of lamotrigine treated epilepsy,re- cently 10 years published original articles were obtained from 3 databases,i.e.MEDLINE,EMBASE and Chinese Journal Fulltext Database (CJFD).Result:Six articles were eligible and recruited.The cost-utility analysis results showed that, comprising carbamazepine treatment group,the cost of lamotrigine for monotherapy partial seizure epilepsy was the lowest ($23,344 per increased a quality adjusted life year,QALY),gabapentin was the must costly ($187,857).While val- proate treatment as a comparison group,the increased cost-utility ratio of lamotrigine monotherapy generalized seizure and unclassifiable epilepsy was higher than that of topiramte.Conclusion:The increase cost-utility ratio of lamotrigine mono- therapy partial seizure epilepsy surpassed topiramate and gabapentin;and of monotherapy generalized seizure and unclassifi- able epilepsy was inferior to topiramate. |
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