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| 左氧氟沙星296例不良反应文献分析 |
| Literature Analysis of 296 Cases of Levofloxacin induced Adverse Drug Reactions |
| 投稿时间：2011-01-16 修订日期：2011-05-06 |
| DOI： |
| 中文关键词: 左氧氟沙星 药品不良反应 文献分析 |
| 英文关键词:Levofloxacin Adverse drug reactions（ADR） Literature analysis |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：探讨左氧氟沙星致不良反应发生的规律及特点，为临床合理用药提供参考。方法：通过中国知网（CNKI）的中国医院知识仓库（CHKD）期刊全文数据库及万方数据库检索到1999～2010年有关左氧氟沙星致不良反应的有效文献322篇，并按患者性别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果：收集左氧氟沙星所致不良反应296例，其中，248例（83.78％）通过静脉途径给药；不良反应以神经系统及全身性损害最多，有79例（26.35％）；其发生时间最早的在用药1 min 内，最迟的在用药2 个月后。结论：左氧氟沙星引起的不良反应临床表现复杂多样，其发生与多种因素有关，最严重的可能引起死亡，值得临床医师关注。 |
| 英文摘要: |
| ABSTRACT Objective:To explore the regularity and characteristics of ADRs induced by levofloxacin. Method:Based on the CHKD and Wanfang database，a total of 322 literatures about levofloxacin induced ADRs were collected and statistically analyzed in respect of patients’gender，age，case history，administration route and clinical manifestation.Result:248 cases (86.78％) were given levofloxacin intravenously. 79 cases (26.35％) presented damages in the nervous system or the whole body. The most immediate ADR occurred within 1 min after administration, while the latest occurred 2 monthes after administration.Conclusion:ADRs induced by levofloxacin presented various complicated symptoms related to different factors, and some ADRs led to death. Clinical doctors should pay more attention to levofloxacin induced ADRs. |
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