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| 282例β-内酰胺类抗菌药的不良反应分析 |
| Analysis for 282 Cases of Adverse Drug Reaction of β lactam Antibiotics |
| 投稿时间：2011-03-09 修订日期：2011-05-15 |
| DOI： |
| 中文关键词: β-内酰胺类抗菌药 药品不良反应 合理用药 |
| 英文关键词:β-lactam antibiotics Adverse drug reaction Rational drug use |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：了解我院2009～2010年β-内酰胺类抗菌药不良反应发生情况, 分析其影响因素, 以促进临床合理用药。方法：收集我院2009～2010年上报告国家药品不良反应监测中心的282例β-内酰胺类抗菌药的药品不良反应（ADR）报告,分别从患者年龄、性别、给药途径、使用药物种类以及临床表现等方面进行统计分析。结果：ADR涉及β-内酰胺类抗菌药共33种, 以头孢曲松居首位, 其次为头孢呋辛和氨曲南; 以静脉途径给药引发的ADR最多;282例ADR中, 大于60 岁患者构成比最高（28.72%）；临床表现以皮肤及其附件损害最常见。结论：β-内酰胺类抗菌药发生ADR 与年龄、给药途径等多种因素相关, 应规范β-内酰胺类抗菌药的临床应用,减少ADR的发生。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the reality and affecting factors of adverse drug reaction(ADR ) induced by β-lactam antibiotics in our hospital during 2009-2010, in order to promote the rational use of drug in clinic. Method:We classified and analyzed 282 cases of ADR of β-lactam antibiotics which is reported to National center for ADR Monitoring during 2009-2010, according to the aspects of patients' age and gender, administration route, species of drugs and clinical manifestations. Result:The ADR were caused by a total of 33 species of β-lactam antibiotics agents, among which Ceftriaxone ranked the first and was followed by Cefuroxime and Aztreonam; The most causing route was intravenous administration; of which, those patients' aged above 60 years accounted for 28.72%;the damage of skin and its annex were the most common clinical manifestations.Conclusion:Multiple factors contributed to the ADR, for example age and administration route. And the clinical application of β-lactam antibiotics of should be regulated to avoid or reduce the occurrence of ADR. |
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