| ABSTRACT Objective: To evaluate and compare the effect of propofol intravenous anesthesia combined with epidural anesthesia on hemodynamic changes in hypertension patients undergoing thoracic surgeries. Method:90 primary hypertension patients undergoing thoracic surgeries were randomly divided into two groups, propofol intravenous anesthesia group (P group) and propofol intravenous anesthesia combined with epidural anesthesia group (P+E group), 45 in each group. Epidural anesthesia was performed via the T7～8or T8～9 interspace. Their propofol target blood concentration was maintained at 2-3 μg·ml-12, CO, CI, SBP, DBP and BIS were continuously monitored in the perioperative period. Their recovery time for spontaneous breath, wake up time and extubation time were also recorded.Result:No significant differences were observed between P group and PE group before anesthesia (T0, P>0.05). 10 min after the anesthesia induction (T1), the patients' SBP, DBP, HR, CO and CI in both groups were obviously lower than at T0 (P<0.05), but there was no statistic difference between the two groups (P>0.05). After thoracotomy (T2), the SBP in P group was higher than at T0 (P<0.01). Meanwhile, the SBP, DBP and CI in PE group were lower than those in P group (P<0.05). No anesthesia accident was observed in both groups. Their recovery time for spontaneous breath, wake up time and extubation time were markedly shorter in PE group than those in P group (P<0.05). Conclusion:Operations were performed effectively with the two anesthesia methods. Propofol intravenous anesthesia combined with epidural anesthesia could maintain the stability of hemodynamics in patients with hypertension. |
