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| 吡格列酮的不良反应病例报告分析 |
| Analysis of Case Reports of Pioglitazone’s Adverse Drug Reaction |
| 投稿时间：2011-05-10 修订日期：2011-07-13 |
| DOI： |
| 中文关键词: 吡格列酮 药品不良反应 心脏衰竭 肝脏衰竭 |
| 英文关键词:Pioglitazone Adverse drug reaction Heart failure Liver failure |
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| 中文摘要: |
| 摘 要 目的：对吡格列酮药品不良反应（ADR）病例报告进行回顾分析，为临床合理安全使用提供参考。方法：以“pioglitazone”为检索词检索Reactions Weekly，将检索到的ADR病例报告分类，分别提取患者的临床特征及ADR类型、转归等信息，进行统计分析。结果：检索到与吡格列酮相关ADR病例报告41份。41名患者中男21例，女19例，1名性别不明。年龄30～82岁，吡格列酮剂量15～45 mg·d-1，疗程1周～2年。发生ADR分别涉及心血管系统、呼吸系统、肝胆系统等多个系统/器官。41名患者中1名转归不明，8名死亡，其余患者停药后或停药经治疗后好转或痊愈。结论：吡格列酮引起的心衰、肝衰竭等ADR会给患者带来较大危害，甚至危及到生命。医务人员在使用吡格列酮的同时，要关注其ADR。 |
| 英文摘要: |
| ABSTRACT Objective:To review and analyze the case reports of pioglitazone’s adverse drug reactions to provide reference for rational and safe use of pioglitazone.Method:Reactions Weekly was searched for case reports with the key word ‘pioglitazone’, types of ADRs of the case reports were classified and the patients’ clinical characteristics, types and outcome of ADRs were analyzed. Result:41 case reports of ADRs associated with pioglitazone were found. 41 patients consisted of 21 males, 19 females and 1 unidentified, and were aged 30-82 years with a pioglitazone’s dosage 15-45 mg per day and its duration from 1 week to 2 years. Their ADRs were involved in many systems such as cardiovascular system, respiratory system and biliary system. Except for 1 patient with unaquired outcome, 8 patients died, the rest recovered after pioglitazone’s discontinuation with or without therapy.Conclusion:Pioglitazone could induce severe adverse reactions such as heart failure and liver failure. The medical staff should monitor ADR as they used piolitazone. |
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