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| 阿立哌唑与氟哌啶醇治疗首发精神分裂症随机对照研究 |
| Randomized Controlled Trials of the Treatment of the First episode Schizophrenia with Aripiprazole and Haloperidol |
| 投稿时间：2011-04-30 修订日期：2011-07-11 |
| DOI： |
| 中文关键词: 精神分裂症 阿立哌唑 氟哌啶醇 |
| 英文关键词:Schizophrenia Aripiprazole Haloperidol |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：评价阿立哌唑治疗首发精神分裂症的临床疗效及安全性。方法：87例首次住院的精神分裂症患者随机分为2组，分别给予阿立哌唑、氟哌啶醇治疗，疗程8周。治疗前及治疗2，4，8周末采用阳性与阴性综合征量表(PANSS)评定疗效，副反应量表(TESS)评定不良反应。结果： 治疗8周末，阿立哌唑组有效率为91.11%；氟哌啶醇组有效率为88.10%；两组差异无统计学意义(P＞0.05)。治疗2周末两组评分均较治疗前下降差异显著(P＜0.01)，随治疗时间的延长两组疗效差距逐渐缩小。结论：阿立哌唑治疗精神分裂症起效时间短于氟哌啶醇，远期疗效优于氟哌啶醇；且安全性高，依从性好。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the efficacy and safety of aripiprazole in the treatment of the first episode schizophrenia. Method:A randomized clinical trial was carried out. 87 patients with the first episode schizophrenia were randomly divided into aripiprazole group and haloperidol group treated with the above drugs separately, the course of treatment being 8 weeks. Their effects and side effects were assessed with the positive and negative syndrome scale (PANSS) and treatment emergent symptoms scale (TESS) respectively 2, 4, 8 weeks before and after the treatment. Result:At the end of 8 weeks’ treatment, the effective response rates in aripiprazole group and haloperidol group were 91.11% and 88.10%, respectively. There were no significant differences between the two groups (P>0.05). At the end of 2 weeks’ treatment, there were significant differences comparing them with the baseline in both groups(P＜0.01) and the differences declined gradually and the differences between the two groups became smaller as the treatment went on.Conclusion:Aripiprazole with its quick function time and long-term efficacy is an effective and safe antipsychotic. |
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