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| 武汉地区7家医院连续5年喹诺酮类药用药频度与细菌耐药性分析 |
| Analysis of the Use Density and Bacterial Resistance of Quinolones in 5 Consecutive Years in Wuhan |
| 投稿时间：2011-08-08 修订日期：2011-10-14 |
| DOI： |
| 中文关键词: 喹诺酮 用药频度 耐药 |
| 英文关键词:Quinolones DDDs Bacterial resistance |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：研究喹诺酮类抗菌药的用量与细菌耐药率之间的关系，促进临床合理用药。方法：回顾性调查武汉地区7家医院2005～2009年喹诺酮类抗菌药的用量，并与监测菌的耐药率做相关分析。结果：大多数监测菌种对喹诺酮类药的耐药率均超过30%；鲍曼不动杆菌对喹诺酮类药的耐药率随喹诺酮类药用量的变化而变化，与喹诺酮类药总用药频度高度相关。结论：喹诺酮类药对多数常见菌种的耐药率较高，其用药频度对细菌耐药性变异也有一定影响。应严格把握喹诺酮类药的临床适应证，加强对喹诺酮类药的管理，以减少或延缓细菌耐药性的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the use density and bacterial resistance of quinolones.Method:The consumption of quinolones in the past 5 years was investigated and the relationship between their consumption and bacterial resistance was statistically analyzed by linear correlation.Result:The resistance rates of most bacteria monitored exceeded the warning line by 30%. With the change of the use density of quinolones, the resistance rates of Acinetobacter baumannii bacteria changed in the past 5 years. There was a highly correlation between the use density of quinolones and the resistance rates of Acinetobacter baumannii bacteria.Conclusion:The bacterial resistance of quinolones was at a high level. The consumption of quinolones could create their affection on the bacterial resistance in some degree. The application of quinolones should be strictly managed to delay the bacterial resistance. |
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