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| 准分子激光屈光性角膜切削术中应用丝裂霉素疗效Meta分析 |
| A Meta analysis of the Outcomes of Photorefractive Keratectomy Correction for Myopia with Mitomycin C |
| 投稿时间：2011-09-09 修订日期：2011-12-26 |
| DOI： |
| 中文关键词: 准分子激光屈光性角膜切削术 Meta分析 丝裂霉素 角膜上皮下雾状混浊 |
| 英文关键词:Photorefractive keratectomy Meta-analysis Mitomycin Haze |
| 基金项目:卫生部科研基金项目（编号：WKJ-2007-2-017） |
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| 中文摘要: |
| 摘 要 目的：探讨准分子激光屈光性角膜切削（PRK）术中使用丝裂霉素（MMC）对抑制角膜上皮下雾状混浊（Haze）的效果及其对角膜内皮细胞的影响。方法：全面检索1981年1月～2010年6月公开发表的关于PRK术中使用0.02%MMC对抑制Haze效果的随机对照试验，对术后Haze发生比例及角膜内皮细胞密度减少量进行Meta分析。结果：共纳入7篇文献，Meta分析结果显示，MMC组比对照组明显地减少了Haze的形成，差异有统计学意义（P<0.000 01）。与对照组相比，MMC组对角膜内皮细胞密度影响差异无统计学意义（P=0.36）。结论：PRK术中使用0.02%MMC可以明显减少术后Haze的形成，对角膜内皮细胞暂未发现有显著影响。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the results of the intraoperative use of 0.02% mitomycin(MMC) to inhibit haze formation and its effect on the number of corneal endothelial cells after photorefractive keratectomy (PRK) correction for myopia. Method:A full search was performed from 1981 to June 2010 to identify all the randomized controlled trials. A meta analysis of the occurrence of corneal haze and the loss of corneal endothelial cells was conducted when 0.02% MMC was used during PRK.Result:The study included seven literatures. The meta analysis showed that the MMC group more greatly decreased the haze formation than the controlled group. The difference was statistically significant (P<0.000 01). The effect of the MMC group on the number of corneal endothelium cell loss had no significant statistical difference (P=0.36). Conclusion:Prophylactic use of 0.02% MMC in PRK surgery could significantly reduce the formation of haze but had no significant effect on the number of the corneal endothelium cell loss |
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