| ABSTRACT Objective: To evaluate the efficacy and safety of the long term administration of adefovir by out patients with hepatitis B. Method:336 patients with chronic hepatitis B receiving adefovir dipivoxil at 10 mg·d-1 between 2005 to 2008 had been followed up for 2 years. Such examinations as urine routine, blood biochemistry, serum HBV DNA, hepatitis B virus serum markers, function of liver and kidney, symptoms and adverse events were recorded.Result: 28 of the 336 patients were selected off, and the loss rate was 8.3%. The abnormal rates of the examination of liver functions, HBV-DNA, α-fetoprotein (AFP) and HBe in serum were significantly improved except blood biochemistry and urine routine. However, the serum creatinine results had an obvious relationship with medication time but sex and age. Adverse events were consistent with previous reports, in which gastrointestinal reaction and hair loss were the most common.Conclusion:The long term administration of adefovir at 10 mg·d-1 in out patients with chronic hepatitis B suppressed the replication of virus and effectively improved the recovery of ALT, but had some light adverse reactions in kidney, which suggests the efficacy, good tolerance and safety of the long term administration of adefovir. |
