| ABSTRACT Objective:To compare the effect of ilaprazole and esomeprazole based triple therapy regimens on duodenal ulcer with helicobacter pylori（Hp）infection. Method:120 patients with duodenal ulcer with Hp infection were randomly divided into 3 groups, which were treated with ilaprazole 15, 20 mg and esomeprazole 20 mg separately, and also given clarithromycin 500 mg and amoxicillin 1 000 mg at the same time twice daily for 10 days. After this treatment, all the patients were given the same dosage of corresponding PPI for 4 weeks, the ulcer, re examined by endoscopy and the Hp, detected. Then the ulcer healing rates and eradication rates of Hp as well as adverse effects of the medication were evaluated and compared. Result:At the end of 2 weeks, the ulcer healing rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 82.5%, 75%, 77.5%（P>0.05）. At the end of 4 weeks, the ulcer healing rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 90%, 87.5% and 87.5%（P>0.05）.The Hp eradication rates of ilaprazole 15, 20 mg and esomeprazole 20 mg were 85%, 82.5% and 90%（P>0.05）.There was no serious adverse reaction.Conclusion:The ilaprazole based triple therapy could eradicate Hp infection, relieve symptoms and promote duodenal ulcer healing effectively and safely. There was no relationship between the efficacy and the dosage. The result also showed that the differences between ilaprazole and esomeprazole were not significant. |
