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| 依巴斯汀治疗慢性荨麻疹临床疗效的Meta分析 |
| Effect and Safety of Ebastine on Chronic Urticaria：A Meta analysis of Randomized Controlled Trials |
| 投稿时间：2011-06-30 修订日期：2011-09-13 |
| DOI： |
| 中文关键词: 依巴斯汀 慢性荨麻疹 Meta分析 |
| 英文关键词:Ebastine Chronic urticaria Meta analysis |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：评价依巴斯汀治疗慢性荨麻疹临床疗效及不良反应。方法：计算机检索 Cochrane 图书馆、PubMed、EMbase、中国知网和万方数据库。检索时间均为建库至2011年2月。收集以依巴斯汀与其他药物对照治疗慢性荨麻疹的随机对照临床试验（RCT）。评价纳入文献的研究质量，提取有效数据，采用RevMan 5.0软件进行Meta分析。结果：共纳入12个研究,包括1 567例慢性荨麻疹患者。Meta分析结果显示，依巴斯汀治疗慢性荨麻疹临床疗效较其他抗组胺药高；依巴斯汀联合用药或其他抗组胺药联合用药治疗慢性荨麻疹临床疗效比单一应用依巴斯汀的疗效高，但复发率比较差异无统计学意义；依巴斯汀治疗慢性荨麻疹的不良反应与依巴斯汀联合用药或其他抗组胺药联合用药比较，差异无统计学意义。结论：依巴斯汀能有效治疗慢性荨麻疹，不良反应少。由于慢性荨麻疹病因复杂，且本次研究仍有局限性，还需要更多大样本、设计严格的随机临床对照试验加以证实。 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the efficacy and safety of ebastine on patients with chronic urticaria(CU).Method:The electronic databases (the Cochrane Library, PubMed, EMbase, CNKI and WANFANG DATA ) were searched in order to retrieve randomized controlled trials(RCT) about comparing ebastine with other drug therapy for CU. The related references were traced to obtain the information. The Jadad’s scale and Cochrane collaboration’s RevMan 5.0soft ware were used to assess the trial methodological quality and data analyses.Result:12 trials involving 1 567 patients were included. The Meta analysis results showed that the efficacy of ebastine was better than that of the treatment with other antihistamine drugs, the effect of ebastine combination therapy or other antihistaminic combination therapy were better than that of the treatment only with ebastine, the difference between the groups of the combination therapy or other antihistaminic combination therapy and only ebastine treatment was not significant in their relapse rate, and there was no significant difference in the number of adverse events between ebastine and combination therapy or other antihistaminic combination therapy.Conclusion:Ebastine is effective and safe in the treatment of CU. However, well designed RCTs with a larger sample size are still needed because of complex factors of CU. |
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