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| 66例吉非替尼不良反应报告分析 |
| Analysis of 66 Cases of Adverse Drug Reactions Induced by Gefitinib |
| 投稿时间：2012-05-14 修订日期：2012-08-18 |
| DOI： |
| 中文关键词: 吉非替尼 药品不良反应 合理用药 |
| 英文关键词:efitinib Adverse drug reactions Rational drug use |
| 基金项目: |
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| 中文摘要: |
| 摘 要 目的：探讨吉非替尼所致的药品不良反应（ADR）特点，为临床合理用药提供参考。方法：收集我院2009～2011年上报至全国ADR监测网络的吉非替尼ADR报告，总共60位患者66例ADR，分别对其患者年龄、性别、用药情况和ADR的临床表现等进行统计分析。结果：66例不良反应中，61～80岁患者发生ADR例数最多（58.33%）；62.13%的ADR在用药1个月内发生；消化系统ADR占28.79%、皮肤及其附件ADR占31.82%、呼吸系统ADR占18.18%；死亡9例。 结论：吉非替尼ADR多数表现轻微，采取适当的处理可提高患者用药依从性。需加强对患者的随访观察，防止严重ADR的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the characteristics and regularity of the adverse drug reactions(ADR) induced by gefitinib to provide reference for clinical rational drug use. Methods:Reports sent to the national ADR monitoring network were collected by the departments of our hospital during 2009～2011. 60 of the 66 cases with ADRs induced by gefitinib were selected and analyzed in age, sex, condition of drug use and clinical symptoms.Results:Of the 66 cases，patients aged 61～80 took up the most(58.33%), 62.13%ADRs occurred within 1 month, ADR of digestive system accounted for 28.79%, lesion of skin and its appendants took up 31.82%，ADR of respiratory system accounted for 18.18%, and 9 patients were dead.Conclusion:Patients compliance could be improved by proper treatment since most ADRs induced by gefitinib were slight. It is necessary to enhance following up observations to patients in order to prevent some serious ADRs. |
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