| ABSTRACT Objective:To investigate the influencing factors of drug-induced arrhythmias to provide reference for clinical practice. Methods:The cases and the controlled group were screened according to their condition with the method of 1∶1 matched case-control study. The single factor and multivariate logistic regression were analyzed by SPSS. Results:By univariate analysis, 8 factors of statistical significance(P<0.05) were filtered out, and then a multivariate logistic regression analysis was made. The results showed that six factors led to drug induced arrhythmias, and their OR (95% CI) respectively was: anti mental disorder drugs ［24.504(7.079-84.827)］, vitamins and trace elements and nutritional drugs ［5.317(1.269-22.274)］, respiratory medicine ［4.040(1.682-9.702)］, concomitant medications ［2.364(1.241-4.503)］, cardiovascular medicine［2.360(1.041-5.350)］ and the original disease being cardiovascular disease ［1.974(1.027-3.797)］. Conclusion:Before treatment some attention should be paid to drug interactions and the original illness being cardiovascular disease. In the treatment with anti mental disorder drugs, vitamins and trace elements and nutritional drugs, respiratory medicine and cardiovascular medicine, close attention should be paid to the patients’ responses and, if necessary, electrolyte and ECG monitoring should be conducted to reduce or avoid drug induced arrhythmias. |
